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La Spada Laboratory
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Applying the Tools of Molecular Genetics, Neuroscience, and Functional Genomics to Understand the Mechanisms of Neurodegenerative Disease
Dr. Albert La Spada  About the Lab 
Publication Spotlight 

Albert R. La Spada, MD, PhDAlbert R. La Spada, MD, PhD, is chief of the Division of Genetics in the Department of Pediatrics. An accomplished clinician and scientist, he is best known for his 1991 discovery of the first trinucleotide repeat disease mutation, setting an entirely new field of research into motion.

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The LaSpada Laboratory primarily studies the molecular basis of the CAG /polyglutamine repeat diseases of which there are nine:

  • Huntington's disease
  • X-linked spinal and bulbar muscular atrophy
  • Dentatorubral-pallidoluysian atrophy
  • And six forms of spinocerebellar ataxia

Current Research

Mutant Protein in Muscle Linked to Neuromuscular Disorder  

Target Identified for Rare Inherited Neurological Disease in Men 

Global Genes Publication

PGC-1α Rescues Huntington’s Disease Proteotoxicity by Preventing Oxidative Stress and Promoting TFEB Function

New Cellular Targets for Devastating Neurological Disorder

Journal of Neuroscience: our research on the Cover.  Vol. 31, No. 45, Nov 9th, 2011

Neuron: Vol. 70, Issue 6, 1071-1084, June 23rd, 2011 link to video abstract

Neuron: Vol. 66, Issue 6, 835-847, June 24th 2010

UC San Diego Health System Newsletter: Our Lab in the Spotlight 
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Science Translational Medicine: Our Research featured
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Journal of Neuroscience: Our Research featured on the Journal Cover.
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NEURON: CTCF Regulates Ataxin-7 Expression through Promotion of a
Convergently Transcribed, Antisense Noncoding RNA
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NEURON: La Spada et al links Nna proteins to mitochondrial dysfunction in neurodegenerative diseases
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SAN DIEGO UNION TRIBUNE: La Spada featured on Genetics for Personalized Medicine
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Institute for Genomic Medicine Summer Retreat